Journal article
Spatial Confinement of Ultrasonic Force Fields in Microfluidic Channels
Department of Physics, Technical University of Denmark1
Department of Micro- and Nanotechnology, Technical University of Denmark2
ChemLabChip Group, LabChip Section, Department of Micro- and Nanotechnology, Technical University of Denmark3
LabChip Section, Department of Micro- and Nanotechnology, Technical University of Denmark4
Theoretical Microfluidics Group, Theory Section, Department of Micro- and Nanotechnology, Technical University of Denmark5
Theory Section, Department of Micro- and Nanotechnology, Technical University of Denmark6
We demonstrate and investigate multiple localized ultrasonic manipulation functions in series in microfluidic chips. The manipulation functions are based on spatially separated and confined ultrasonic primary radiation force fields, obtained by local matching of the resonance condition of the microfluidic channel.
The channel segments are remotely actuated by the use of frequency-specific external transducers with refracting wedges placed on top of the chips. The force field in each channel segment is characterized by the use of micrometer-resolution particle image velocimetry ( micro-PIV). The confinement of the ultrasonic fields during single-or dual-segment actuation, as well as the cross-talk between two adjacent. fields, is characterized and quantified.
Our results show that the field confinement typically scales with the acoustic wavelength, and that the cross-talk is insignificant between adjacent. fields. The goal is to define design strategies for implementing several spatially separated ultrasonic manipulation functions in series for use in advanced particle or cell handling and processing applications.
One such proof-of-concept application is demonstrated, where. flow-through-mode operation of a chip with. flow splitting elements is used for two-dimensional pre-alignment and addressable merging of particle tracks.
Language: | English |
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Year: | 2009 |
Pages: | 112-119 |
ISSN: | 18749968 and 0041624x |
Types: | Journal article |
DOI: | 10.1016/j.ultras.2008.06.012 |
ORCIDs: | Bruus, Henrik |