Journal article
New insights into the impact of primary lung adenocarcinoma location on metastatic sites and sequence: A multicenter cohort study
Medical University of Vienna1
University Hospital Essen2
National Korányi Institute of TB and Pulmonology3
Semmelweis University4
County Hospital of Pulmonology5
University of Debrecen6
Szent György Hospital7
Eotvos Lorand University8
Cancer Genomics, Department of Bio and Health Informatics, Technical University of Denmark9
Department of Bio and Health Informatics, Technical University of Denmark10
...and 0 moreIntroduction: The presence of organ metastases is a major factor for unfavorable prognosis in lung adenocarcinoma (LADC). However, the influence of primary tumor location on metastatic sites and sequence has not been extensively analyzed. Methods: We performed a multicenter cohort study, evaluating clinicopathological data of 1126 Caucasian LADC patients, focusing on the distinct location of primary tumors and metastatic sites during disease progression.
Results: Metastases to the lung (p < 0.001), pleura (p < 0.001) and adrenal glands (p < 0.001) occurred earlier during disease progression and central primary tumors were associated with early metastases (OR 1.43, p = 0.02). In secondary exploratory analysis we found that bone metastases were more frequent in patients with central tumors (OR 1.86, p = 0.017), whereas lung metastases in those with peripheral tumors (OR 1.35, p = 0.015).
Central primary LADCs were associated with decreased median overall survival (vs. peripheral tumors, 10.2 vs. 22 months) both in univariate (HR 2.075, p = 0.001) and in multivariate (HR 1.558, p < 0.001) analyses and independent from stage and T factor. By subsequent analysis, we found that bone metastases tend to appear together with adrenal and liver metastases, and adrenal with skin, and pleural with pericardial metastases more frequently than expected if metastatic events occurred independently.
Conclusion: This comprehensive large cohort analysis demonstrates metastatic site- and sequence-specific variations in patients with LADC. Central LADC is associated with early metastatic disease, bone involvement and, consequently, decreased survival.
Language: | English |
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Year: | 2018 |
Pages: | 139-148 |
ISSN: | 18728332 and 01695002 |
Types: | Journal article |
DOI: | 10.1016/j.lungcan.2018.11.004 |
ORCIDs: | 0000-0001-9425-1748 |