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Journal article

Future directions for in-situ product removal (ISPR)

From

Center for BioProcess Engineering, Department of Chemical and Biochemical Engineering, Technical University of Denmark1

Department of Chemical and Biochemical Engineering, Technical University of Denmark2

Xendo Manufacturing BV3

Delft University of Technology4

This paper summarizes the main findings of a round-table discussion held to examine the key bottlenecks in the further application and industrial implementation of in-situ product removal (ISPR) techniques. It is well established that ISPR can yield great benefits for processes limited by inhibitory or toxic products, as wen as unstable products or reactions that are thermodynamically unfavorable.

However, several issues for industrial implementation were revealed in the discussion. Most notably implementation will be dependent on (1) research into the appropriate process structure, (2) methods to achieve process robustness, (3) systematic selection methods for separation operations and (4) the nature of the product market.

Here, these four issues will be discussed as a basis for future work in this area.

Language: English
Publisher: John Wiley & Sons, Ltd.
Year: 2008
Pages: 121-123
ISSN: 10974660 , 02682575 and 03681084
Types: Journal article
DOI: 10.1002/jctb.1790
ORCIDs: Woodley, John

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