Journal article
Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis
Department of Micro- and Nanotechnology, Technical University of Denmark1
Nanoprobes, Department of Micro- and Nanotechnology, Technical University of Denmark2
Technical University of Denmark3
Silicon Microtechnology, Department of Micro- and Nanotechnology, Technical University of Denmark4
University of Copenhagen5
Vienna University of Technology6
Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark7
Standard infrared spectroscopy techniques are well-developed and widely used. However, they typically require milligrams of sample and can involve time-consuming sample preparation. A promising alternative is represented by nanomechanical infrared spectroscopy (NAM-IR) based on the photothermal response of a nanomechanical resonator, which enables the chemical analysis of picograms of analyte directly from a liquid solution in only a few minutes.
Herein, we present NAM-IR using perforated membranes (filters). The method was tested with the pharmaceutical compound indomethacin to successfully perform a chemical and morphological analysis on roughly 100 pg of sample. With an absolute estimated sensitivity of 109±15 fg, the presented method is suitable for ultrasensitive vibrational spectroscopy.
| Language: | English |
|---|---|
| Year: | 2017 |
| Pages: | 3901-3905 |
| ISSN: | 15213773 and 14337851 |
| Types: | Journal article |
| DOI: | 10.1002/anie.201700052 |
| ORCIDs: | Nielsen, Line Hagner , Hansen, Ole , Boisen, Anja and 0000-0002-7521-6020 |
