Journal article
Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study
National Institute of Occupational Health, Lersø Parkallé 105, DK-2100 Copenhagen, Denmark. ubv@ami.dk1
Homozygous carriers of a haplotype consisting of ERCC1 Asn118Asn(A), ASE-1 G-21A(G), RAI IVS1 A4364G(A) are at increased risk of lung cancer especially among women. Here, we analyse for gene-environment interactions with the predefined haplotype in a case cohort study including 428 lung cancer cases and a comparison group of 800 persons, all from the prospective Diet, Cancer and Health cohort of 57,000 Danes.
At high smoking intensity (>20g tobacco/day), there was only additional risk of smoking intensity among women who were homozygous carriers of the haplotype (IRR=2.03; 95% CI: 1.10-3.73 per 5 additional g tobacco/day).
Language: | English |
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Year: | 2007 |
Pages: | 159-165 |
ISSN: | 18727980 and 03043835 |
Types: | Journal article |
DOI: | 10.1016/j.canlet.2006.04.001 |
ORCIDs: | Overvad, Kim |
Adult Aged Apoptosis Cohort Studies DNA-Binding Proteins ERCC1 protein, human Endonucleases Female Genetic Predisposition to Disease Haplotypes Humans Intracellular Signaling Peptides and Proteins Lung Neoplasms Lung cancer Male Middle Aged POLR1G protein, human PPP1R13L protein, human Polymorphism, Genetic Population Surveillance Population-based RNA Polymerase I Repressor Proteins Risk Factors SNPs Smoking