Journal article
Liposome accumulation in irradiated tumors display important tumor and dose dependent differences
Department of Micro- and Nanotechnology, Technical University of Denmark1
Technical University of Denmark2
Colloids and Biological Interfaces, Department of Micro- and Nanotechnology, Technical University of Denmark3
University of Copenhagen4
Center for Nuclear Technologies, Technical University of Denmark5
The Hevesy Laboratory, Center for Nuclear Technologies, Technical University of Denmark6
Radioecology and Tracer Studies, Center for Nuclear Technologies, Technical University of Denmark7
Radiation therapy may affect several important parameters in the tumor microenvironment and thereby influence the accumulation of liposomes by the enhanced permeability and retention (EPR)-effect. Here we investigate the effect of single dose radiation therapy on liposome tumor accumulation by PET/CT imaging using radiolabeled liposomes.
Head and neck cancer xenografts (FaDu) and syngenic colorectal (CT26) cancer models were investigated. Radiotherapy displayed opposite effects in the two models. FaDu tumors displayed increased mean accumulation of liposomes for radiation doses up to 10 Gy, whereas CT26 tumors displayed a tendency for decreased accumulation.
Tumor hypoxia was found negatively correlated to microregional distribution of liposomes. However, liposome distribution in relation to hypoxia was improved at lower radiation doses. The study reveals that the heterogeneity in liposome tumor accumulation between tumors and different radiation protocols are important factors that need to be taken into consideration to achieve optimal effect of liposome based radio-sensitizer therapy.
| Language: | English |
|---|---|
| Year: | 2018 |
| Pages: | 27-34 |
| ISSN: | 15499642 and 15499634 |
| Types: | Journal article |
| DOI: | 10.1016/j.nano.2017.08.013 |
| ORCIDs: | 0000-0002-0285-024X , 0000-0002-2706-5547 , Hansen, Anders Elias , Henriksen, Jonas Rosager , Elema, Dennis Ringkjøbing and Andresen, Thomas Lars |
Animals Colorectal Neoplasms Colorectal Neoplasms/diagnostic imaging Copper Radioisotopes Copper Radioisotopes/administration & dosage Female Gamma Rays Gamma Rays/therapeutic use Head and Neck Neoplasms Head and Neck Neoplasms/diagnostic imaging Humans Hypoxia/metabolism Liposomes Liposomes/administration & dosage Mice Mice, Nude Positron Emission Tomography Computed Tomography Positron Emission Tomography Computed Tomography/methods Radiation Dosage Tissue Distribution Treatment Outcome Tumor Cells, Cultured Xenograft Model Antitumor Assays
