Journal article
Major and minor arsenic compounds accounting for the total urinary excretion of arsenic following intake of blue mussels (Mytilus edulis): A controlled human study
Oslo and Akershus University College of Applied Sciences1
Statistics Norway2
National Institute of Nutrition and Seafood Research3
National Food Institute, Technical University of Denmark4
Division of Food Chemistry, National Food Institute, Technical University of Denmark5
Institute for Chemistry-Analytical Chemistry6
Norwegian Institute of Public Health7
Blue mussels (Mytilus edulis) accumulate and biotransform arsenic (As) to a larger variety of arsenicals than most seafood. Eight volunteers ingested a test meal consisting of 150g blue mussel (680μg As), followed by 72h with an identical, low As controlled diet and full urine sampling. We provide a complete speciation, with individual patterns, of urinary As excretion.
Total As (tAs) urinary excretion was 328±47μg, whereof arsenobetaine (AB) and dimethylarsinate (DMA) accounted for 66% and 21%, respectively. Fifteen minor urinary arsenicals were quantified with inductively coupled plasma mass spectrometry (ICPMS) coupled to reverse-phase, anion and cation-exchange high performance liquid chromatography (HPLC).
Thio-arsenicals and non-thio minor arsenicals (including inorganic As (iAs) and methylarsonate (MA)) contributed 10% and 7% of the total sum of species excretion, respectively, but there were large individual differences in the excretion patterns. Apparently, formation of thio-arsenicals was negatively correlated to AB formation and excretion, possibly indicating a metabolic interrelationship.
The results may be of toxicological relevance since DMA and MA have been classified as possibly carcinogenic, and six of the excreted As species were thio-arsenicals which recently have been recognized as toxic, while iAs toxicity is well known.
Language: | English |
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Year: | 2012 |
Pages: | 2462-2472 |
ISSN: | 18736351 and 02786915 |
Types: | Journal article |
DOI: | 10.1016/j.fct.2012.04.026 |
ORCIDs: | Sloth, Jens Jørgen |