About

Log in?

DTU users get better search results including licensed content and discounts on order fees.

Anyone can log in and get personalized features such as favorites, tags and feeds.

Log in as DTU user Log in as non-DTU user No thanks

DTU Findit
Boolean: (bicycle AND helmet) OR (head AND protection) (always group AND in parenthesis)
Title: title:(climate change)
Author: author:("bohr niels" OR "bohr n") (avoid only full first name)
Phrase: "water pump control" (does not work with wildcards)
Wildcards: wom?n pharm*

More help on how to search

Flexible matching

About search syntax

Search syntax Advanced
Close advanced
{{problem}}
By field Using AND/OR By author
This tool can help you build boolean queries suitable for doing a broad search for different synonyms or spellings of each word. Start via the drop-down below or just start typing in the search field.
{{ row.typeTitle }}: ( )

Since our index often lack the full first name of people it can be difficult to correctly search by author.

Fill in the fields and let us help you build a good query:

If you need to find everything possible, consider only searching by last name.

Use "Starting year" to ignore publications out of year range.

More...

Journal article

Lipid Nanoparticles for Delivery of Therapeutic RNA Oligonucleotides

By Moss, Keith Henry1,2,3; Popova, Petya4; Hadrup, Sine Reker1,2,3; Astakhova, Kira4; Taskova, Maria4

From

T-Cells and Cancer, Experimental & Translational Immunology, Department of Health Technology, Technical University of Denmark1

Experimental & Translational Immunology, Department of Health Technology, Technical University of Denmark2

Department of Health Technology, Technical University of Denmark3

Department of Chemistry, Technical University of Denmark4

Gene therapy is an exciting field that has the potential to address emerging scientific and therapeutic tasks. RNA-based gene therapy has made remarkable progress in recent decades. Nevertheless, efficient targeted delivery of RNA therapeutics is still a prerequisite for entering the clinics. In this review, we introduce current delivery methods for RNA gene therapeutics based on lipid nanoparticles (LNPs).

We focus on the clinical appeal of recent RNA NPs and discuss existing challenges of fabrication and screening LNP candidates for effective translation into drugs of human metabolic diseases and cancer.

Language: English
Publisher: American Chemical Society
Year: 2019
Pages: 2265-2277
ISSN: 15438392 and 15438384
Types: Journal article
DOI: 10.1021/acs.molpharmaceut.8b01290
ORCIDs: Moss, Keith Henry , Hadrup, Sine Reker , Astakhova, Kira and 0000-0002-9727-2496
Keywords

Delivery Gene therapy LNP fabrication LNP screening Lipid nanoparticle (LNP) RNA SDG 3 - Good Health and Well-being

Other keywords

Animals Genetic Therapy Humans Lipids Nanoparticles Oligonucleotides delivery gene therapy lipid nanoparticle (LNP) lipidnanoparticle (LNP)

DTU users get better search results including licensed content and discounts on order fees.

Log in as DTU user

Access

Analysis