Journal article
Mutations in 23S rRNA Confer Resistance against Azithromycin in Pseudomonas aeruginosa
Department of Systems Biology, Technical University of Denmark1
National Food Institute, Technical University of Denmark2
Division of Food Microbiology, National Food Institute, Technical University of Denmark3
Center for Systems Microbiology, Department of Systems Biology, Technical University of Denmark4
Copenhagen University Hospital Herlev and Gentofte5
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark6
Bacterial Cell Factories, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark7
The emergence of antibiotic-resistant Pseudomonas aeruginosa is an important concern in the treatment of long-term airway infections in cystic fibrosis patients. In this study, we report the occurrence of azithromycin resistance among clinical P. aeruginosa DK2 isolates. We demonstrate that resistance is associated with specific mutations (A2058G, A2059G, and C2611T in Escherichia coli numbering) in domain V of 23S rRNA and that introduction of A2058G and C2611T into strain PAO1 results in azithromycin resistance.
Language: | English |
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Publisher: | American Society for Microbiology |
Year: | 2012 |
Pages: | 4519-4521 |
ISSN: | 10986596 , 00664804 and 10706283 |
Types: | Journal article |
DOI: | 10.1128/AAC.00630-12 |
ORCIDs: | Marvig, Rasmus Lykke , Søndergaard, Mette S. R. , Molin, Søren , Jelsbak, Lars and 0000-0002-1347-725X |