Journal article
Evaluation method for the drying performance of enzyme containing formulations
A method is presented for fast and cheap evaluation of the performance of enzyme containing formulations in terms of preserving the highest enzyme activity during spray drying. The method is based on modeling the kinetics of the thermal inactivation reaction which occurs during the drying process. Relevant kinetic parameters are determined from differential scanning calorimeter (DSC) experiments and the model is used to simulate the severity of the inactivation reaction for temperatures and moisture levels relevant for spray drying.
After conducting experiments and subsequent simulations for a number of different formulations it may be deduced which formulation performs best. This is illustrated by a formulation design study where 4 different enzyme containing formulations are evaluated. The method is validated by comparison to pilot scale spray dryer experiments.
Language: | English |
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Year: | 2008 |
Pages: | 121-129 |
ISSN: | 1873295x and 1369703x |
Types: | Journal article |
DOI: | 10.1016/j.bej.2007.11.024 |
ORCIDs: | Jensen, Anker Degn and Kiil, Søren |