Journal article
Injection-Molded Microfluidic Device for SERS Sensing Using Embedded Au-Capped Polymer Nanocones
Department of Micro- and Nanotechnology, Technical University of Denmark1
Nanoprobes, Department of Micro- and Nanotechnology, Technical University of Denmark2
Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark3
Optofluidics, Department of Micro- and Nanotechnology, Technical University of Denmark4
Polymer Micro & Nano Engineering, Department of Micro- and Nanotechnology, Technical University of Denmark5
To enable affordable detection and diagnostic, there is a need for low-cost and mass producible miniaturized sensing platforms. We present a fully polymeric microfluidic lab-on-a-chip device with integrated gold (Au)-capped nanocones for sensing applications based on surface-enhanced Raman spectroscopy (SERS).
All base components of the device were fabricated via injection molding (IM) and can be easily integrated using ultrasonic welding. The SERS sensor array, embedded in the bottom of a fluidic channel, was created by evaporating Au onto IM nanocone structures, resulting in densely packed Au-capped SERS active nanostructures.
Using a Raman active model analyte, trans-1,2-bis-(4-pyridyl)-ethylene, we found a surface-averaged SERS enhancement factor of ∼5 × 106 with a relative standard deviation of 14% over the sensor area (2 × 2 mm2), and a 18% signal variation among substrates. This reproducible fabrication method is cost-effective, less time consuming, and allows mass production of fully integrated polymeric, microfluidic systems with embedded high-density and high-aspect ratio SERS sensor.
Language: | English |
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Publisher: | American Chemical Society |
Year: | 2018 |
Pages: | 37417-37425 |
ISSN: | 19448252 and 19448244 |
Types: | Journal article |
DOI: | 10.1021/acsami.8b13424 |
ORCIDs: | Viehrig, Marlitt , Wu, Kaiyu , Zor, Kinga and Boisen, Anja |
Chemical sensing Lab-on-a-chip Microfluidics Plasmonic Polymer injection molding SERS SERS substrates
chemical sensing lab-on-a-chip microfluidics plasmonic polymer injection molding