Journal article
MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer
Department of Clinical Pharmacology, Rigshospitalet, University Hospital Copenhagen, Copenhagen N1
Department of Oncology, Rigshospitalet, Copenhagen Ø2
Department of Pathological Anatomy and Cytology, Rigshospitalet, Copenhagen Ø3
Department for Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Søborg, Denmark and Institute for Science, Systems and Models, University of Roskilde, Roskilde4
Department of Biostatistics, University of Copenhagen, København K, Denmark5
Background: Methylenetetrahydrofolate reductase is a pivotal enzyme in folate metabolism and 5-fluorouracil (5-FU) cytotoxicity. Two common single-nucleotide polymorphisms (SNPs), MTHFR 677C>T (rs1801133) and 1298A>C (rs1801131), reduce enzyme activity. Initially, these SNPs were claimed to predict clinical efficacy, but further studies have yielded contradictory results.
We tested whether these two polymorphisms are determinants of clinical outcome in a large patient group with a long follow-up time.
| Language: | Undetermined |
|---|---|
| Publisher: | Oxford University Press |
| Year: | 2009 |
| Pages: | 1660-1666 |
| ISSN: | 15698041 and 09237534 |
| Types: | Journal article |
| DOI: | 10.1093/annonc/mdp046 |
