Journal article
Bovine colostrum is superior to enriched formulas in stimulating intestinal function and necrotising enterocolitis resistance in preterm pigs
Milk contains immunomodulatory compounds that may be important to protect the immature intestine in preterm neonates from harmful inflammatory reactions involved in disorders like necrotising enterocolitis (NEC). We hypothesised that bovine colostrum and milk formulas enriched with sialic acids (SL), gangliosides (Gang) or osteopontin (OPN) would improve gastrointestinal function and NEC resistance in preterm neonates.
Forty-seven caesarean-delivered preterm pigs were given total parenteral nutrition for 2 d followed by 1.5 d of enteral feeding. In Expt 1, a control formula was compared with an OPN-enriched formula (n 13), while Expt 2 compared a control formula with bovine colostrum or formulas enriched with Gang or SL (n 4-6).
OPN enrichment decreased NEC severity relative to control formula (P
| Language: | English |
|---|---|
| Publisher: | Cambridge University Press |
| Year: | 2011 |
| Pages: | 44-53 |
| ISSN: | 14752662 and 00071145 |
| Types: | Journal article |
| DOI: | 10.1017/S0007114510003168 |
| ORCIDs: | 0000-0001-7480-6064 |
Animals Animals, Newborn Bacteria Bone Marrow Cattle Cell Line Cytokines Dendritic Cells Digestion Disease Models, Animal Dose-Response Relationship, Drug Enterocolitis, Necrotizing Female Food, Formulated Food, Fortified Gangliosides Intestine, Small Milk Milk Proteins Nutritional Support Osteopontin Pregnancy Premature Birth Sialic Acids Swine
