Journal article
A prospective study of artificially sweetened beverage intake and cardiometabolic health among women at high risk
National Cancer Institute United States1
University of Copenhagen2
Research Group for Risk Benefit, National Food Institute, Technical University of Denmark3
National Food Institute, Technical University of Denmark4
Rutgers - The State University of New Jersey, Newark5
Statens Serum Institut6
Tulane University7
Glotech, Inc.8
Kaiser Permanente9
University of California at San Francisco10
University of California at Los Angeles11
National Institutes of Health12
...and 2 moreBackground: Artificially sweetened beverages (ASBs) are commonly consumed and recommended for individuals at high risk for cardiometabolic diseases; however, the health effects of ASBs remain contradictory. Given that cross-sectional analyses are subject to reverse causation, prospective studies with long-term follow-up are needed to evaluate associations between ASBs and cardiometabolic health, especially among high-risk individuals.
Objective: The aim of this studywas to examine associations of ASB intake and cardiometabolic health among high-riskwomenwith prior gestational diabetes mellitus (GDM). Methods: We included 607 women with GDM from the Danish National Birth Cohort (DNBC; 1996-2002) who completed a clinical exam 9-16 y after the DNBC pregnancy for the Diabetes & Women's Health (DWH) Study (2012-2014).
We assessed ASB intake using FFQs completed during the DNBC pregnancy and at the DWH Study clinical exam. We examined cardiometabolic outcomes at the DWH clinical exam. We estimated percentage differences in continuous cardiometabolic markers and RRs for clinical endpoints in association with ASB intake both during pregnancy and at follow-up adjusted for prepregnancy BMI, diet, and lifestyle factors.
Sensitivity analyses to account for reverse causation were performed. Results: In pregnancy and at follow-up, 30.4% and 36.4% of women regularly (≥2 servings/wk) consumed ASB, respectively. Consumption of ASBs, both during pregnancy and at follow-up, was associated with higher glycated hemoglobin (HbA1c), insulin, HOMA-IR, triglycerides, liver fat, and adiposity and with lower HDL at follow-up.
After adjustment for covariates, particularly prepregnancy BMI, the majority of associations between ASB intake in pregnancy and outcomes at follow-up became null with the exception of HbA1c. ASB intake at follow-up (≥1 serving/d compared with <1 serving/mo) was associated with higher HbA1c (6.5%; 95% CI: 1.9, 11.3; P-trend = 0.007); however, associations were not upheld in sensitivity analyses for reverse causation.
Conclusions: Among Danish women with a history of GDM, ASB intake was not significantly associated with cardiometabolic profiles.
| Language: | English |
|---|---|
| Publisher: | Oxford University Press |
| Year: | 2019 |
| Pages: | 221-232 |
| ISSN: | 19383207 and 00029165 |
| Types: | Journal article |
| DOI: | 10.1093/ajcn/nqz094 |
| ORCIDs: | 0000-0003-4312-708X , 0000-0003-2587-4022 , 0000-0002-0628-5292 , 0000-0002-3713-1683 , 0000-0003-0084-2630 , 0000-0002-7296-738X , 0000-0002-6618-5082 , 0000-0001-8322-0495 and 0000-0002-6106-3115 |
Artificially sweetened beverages Cardiometabolic health Diabetes Diet Gestational diabetes Nonnutritive sweeteners Obesity SDG 3 - Good Health and Well-being Soda
Adult Beverages Body Mass Index Cardiovascular Diseases Cohort Studies Denmark Diabetes Mellitus, Type 2 Diabetes, Gestational Female Follow-Up Studies Glycated Hemoglobin Glycated Hemoglobin A Humans Metabolic Diseases Pregnancy Prospective Studies Risk Factors Sweetening Agents Women's Health artificially sweetened beverages cardiometabolic health diabetes diet gestational diabetes nonnutritive sweeteners obesity soda
