Journal article
Injectable Colloidal Gold for Use in Intrafractional 2D Image-Guided Radiation Therapy
Department of Micro- and Nanotechnology, Technical University of Denmark1
University of Copenhagen2
Department of Applied Mathematics and Computer Science, Technical University of Denmark3
Visual Computing, Department of Applied Mathematics and Computer Science, Technical University of Denmark4
Colloids and Biological Interfaces, Department of Micro- and Nanotechnology, Technical University of Denmark5
Department of Chemistry, Technical University of Denmark6
Organic Chemistry, Department of Chemistry, Technical University of Denmark7
Copenhagen University Hospital Herlev and Gentofte8
In the western world, approximately 50% of all cancer patients receive radiotherapy alone or in combination with surgery or chemotherapy. Image-guided radiotherapy (IGRT) has in recent years been introduced to enhance precision of the delivery of radiation dose to tumor tissue. Fiducial markers are often inserted inside the tumor to improve IGRT precision and to enable monitoring of the tumor position during radiation therapy.
In the present article, a liquid fiducial tissue marker is presented, which can be injected into tumor tissue using thin and flexible needles. The liquid fiducial has high radio-opacity, which allows for marker-based image guidance in 2D and 3D X-ray imaging during radiation therapy. This is achieved by surface-engineering gold nanoparticles to be highly compatible with a carbohydrate-based gelation matrix.
The new fiducial marker is investigated in mice where they are highly biocompatible and stable after implantation. To investigate the clinical potential, a study is conducted in a canine cancer patient with spontaneous developed solid tumor in which the marker is successfully injected and used to align and image-guide radiation treatment of the canine patient.
It is concluded that the new fiducial marker has highly interesting properties that warrant investigations in cancer patients.
Language: | English |
---|---|
Year: | 2015 |
Pages: | 856-863 |
ISSN: | 21922659 and 21922640 |
Types: | Journal article |
DOI: | 10.1002/adhm.201400651 |
ORCIDs: | Christensen, Anders Nymark , Hansen, Anders Elias , Bruun, Linda Maria , Clausen, Mads Hartvig , Conradsen, Knut , Larsen, Rasmus , Andresen, Thomas Lars , 0000-0002-0285-024X and 0000-0002-2706-5547 |