Journal article
Co-circulation of two extremely divergent serotype SAT 2 lineages in Kenya highlights challenges to foot-and-mouth disease control
Amongst the SAT serotypes of foot-and-mouth disease virus (FMDV), the SAT 2 serotype is the most widely distributed throughout sub-Saharan Africa. Kenyan serotype SAT 2 viruses have been reported to display the highest genetic diversity for the serotype globally. This complicates diagnosis and control, and it is essential that patterns of virus circulation are known in order to overcome these difficulties.
This study was undertaken to establish patterns of evolution of FMDV serotype SAT 2 in Kenya using complete VP1 coding sequences in a dataset of 65 sequences from Africa, collected over a period of 50 years. Two highly divergent lineages were observed to co-circulate, and occasional trans-boundary spread was inferred, emphasizing the value of constant monitoring and characterization of field strains for improved diagnosis and appropriate vaccine application as well as the need for regional approaches to control.
Language: | English |
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Publisher: | Springer Vienna |
Year: | 2010 |
Pages: | 1625-1630 |
Journal subtitle: | Official Journal of the Virology Division of the International Union of Microbiological Societies |
ISSN: | 14328798 and 03048608 |
Types: | Journal article |
DOI: | 10.1007/s00705-010-0742-9 |
ORCIDs: | Belsham, Graham , 0000-0001-6583-6923 and 0000-0001-5757-3131 |
African Buffalo Animals Biomedicine Buffalo Population Capsid Proteins Cell Line Cluster Analysis Cricetinae Foot-and-Mouth Disease Foot-and-Mouth Disease Virus Genetic Variation Genotype High Posterior Density Infectious Diseases Kenya Maximum Clade Credibility Tree Medical Microbiology Molecular Epidemiology Phylogeny Sequence Analysis, DNA Sequence Homology Serotyping VP1 protein, Foot-and-mouth disease virus Vaccine Strain Virology