Journal article
CTX-M-1 β-lactamase expression in Escherichia coli is dependent on cefotaxime concentration, growth phase and gene location
University of Copenhagen1
Odense University Hospital2
Department of Systems Biology, Technical University of Denmark3
Drug Resistance and Community Dynamics, Department of Systems Biology, Technical University of Denmark4
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark5
Bacterial Cell Factories, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark6
blaCTX-M-1 mRNA expression and CTX-M-1 protein levels were dependent on cefotaxime concentration, growth phase and gene location. These results provide insight into the expression of cephalosporin resistance in CTX-M-1-producing E. coli, improving our understanding of the relationship between antimicrobial therapy and the expression of resistance mechanisms.
| Language: | English |
|---|---|
| Publisher: | Oxford University Press |
| Year: | 2015 |
| Pages: | 62-70 |
| ISSN: | 14602091 and 03057453 |
| Types: | Journal article |
| DOI: | 10.1093/jac/dku332 |
| ORCIDs: | Sommer, Morten Otto Alexander , 0000-0003-2417-0787 and 0000-0001-6225-6587 |
Anti-Bacterial Agents Cefotaxime Chromosomes, Bacterial Escherichia coli Faculty of Health and Medical Sciences Gene Expression Profiling Gene Expression Regulation, Bacterial Gene Expression Regulation, Enzymologic Genes, Bacterial Mass Spectrometry Microbial Sensitivity Tests Original research Plasmids Real-Time Polymerase Chain Reaction antimicrobial resistance beta-Lactamases beta-lactamase TEM-3 regulation regulations
