Journal article
Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark1
Research Groups, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark2
Bacterial Signal Transduction, Research Groups, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark3
Chalmers University of Technology4
The application of nanotechnology for the treatment of cancer is mostly based on early tumor detection and diagnosis by nanodevices capable of selective targeting and delivery of chemotherapeutic drugs to the specific tumor site. Due to the remarkable properties of gold nanoparticles, they have long been considered as a potential tool for diagnosis of various cancers and for drug delivery applications.
These properties include high surface area to volume ratio, surface plasmon resonance, surface chemistry and multi-functionalization, facile synthesis, and stable nature. Moreover, the non-toxic and non-immunogenic nature of gold nanoparticles and the high permeability and retention effect provide additional benefits by enabling easy penetration and accumulation of drugs at the tumor sites.
Various innovative approaches with gold nanoparticles are under development. In this review, we provide an overview of recent progress made in the application of gold nanoparticles in the treatment of cancer by tumor detection, drug delivery, imaging, photothermal and photodynamic therapy and their current limitations in terms of bioavailability and the fate of the nanoparticles.
Language: | English |
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Publisher: | MDPI |
Year: | 2018 |
Pages: | 1979 |
ISSN: | 14220067 and 16616596 |
Types: | Journal article |
DOI: | 10.3390/ijms19071979 |
ORCIDs: | Singh, Priyanka , Garg, Abhroop and Mijakovic, Ivan |
Biocompatibility Cancer Clinical trials Drug delivery Gold nanoparticles Photodynamic therapy Photoimaging Photothermal therapy Protein corona SDG 3 - Good Health and Well-being Toxicology
Biology (General) Chemistry Drug Carriers Gold Humans Materials Testing Metal Nanoparticles Neoplasms Phototherapy QD1-999 QH301-705.5 biocompatibility cancer clinical trials drug delivery gold nanoparticles photodynamic therapy photoimaging photothermal therapy protein corona toxicology