Journal article
Biodegradable microcontainers - towards real life applications of microfabricated systems for oral drug delivery
Drug Delivery and Sensing, Department of Health Technology, Technical University of Denmark1
Department of Physics, Technical University of Denmark2
Biomaterial Microsystems, Nanofabrication, National Centre for Nano Fabrication and Characterization, Technical University of Denmark3
Nanofabrication, National Centre for Nano Fabrication and Characterization, Technical University of Denmark4
National Centre for Nano Fabrication and Characterization, Technical University of Denmark5
Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark6
University of Copenhagen7
Technical University of Denmark8
Department of Health Technology, Technical University of Denmark9
Nanoprobes, Drug Delivery and Sensing, Department of Health Technology, Technical University of Denmark10
...and 0 moreMicrofabrication techniques have been applied to develop micron-scale devices for oral drug delivery with a high degree of control over size, shape and material composition. Recently, microcontainers have been introduced as a novel approach to obtain unidirectional release to avoid luminal drug loss, enhance drug permeation, protect drug payload from the harsh environment of the stomach, and explore the ability for targeted drug delivery.
However, in order to eventually pave the way for real life applications of these microfabricated drug delivery systems, it is necessary to fabricate them in biodegradable materials approved for similar applications and with strategies that potentially allow for large scale production. In this study, we for the first time evaluate biodegradable microcontainers for oral drug delivery.
Asymmetric poly-ε-caprolactone (PCL) microcontainers with a diameter of 300 μm and a volume of 2.7 nL are fabricated with a novel single-step fabrication process. The microcontainers are loaded with the model drug paracetamol and coated with an enteric pH-sensitive Eudragit® S100 coating to protect the drug until it reaches the desired location in the small intestine.
In vitro dissolution studies are performed to assess the drug load and release profile of the PCL microcontainers. Finally, in vivo studies in rats showed a higher bioavailability compared to conventional dosage forms and confirm the potential of biodegradable microcontainers for oral drug delivery.
Language: | English |
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Publisher: | The Royal Society of Chemistry |
Year: | 2019 |
Pages: | 2905-2914 |
ISSN: | 14730189 and 14730197 |
Types: | Journal article |
DOI: | 10.1039/c9lc00527g |
ORCIDs: | 0000-0003-3020-8892 , 0000-0002-1745-0580 , 0000-0002-8857-4943 , Mazzoni, Chiara , Nielsen, Line Hagner , Gundlach, Carsten , Petersen, Ritika Singh , Boisen, Anja and Keller, Stephan Sylvest |