Journal article
Cerebral 5-HT2A receptor binding is increased in patients with Tourette's syndrome
Experimental and clinical data have suggested that abnormalities in the serotonergic neurotransmissions in frontal-subcortical circuits are involved in Tourette's syndrome. To test the hypothesis that the brain's 5-HT2A receptor binding is increased in patients with Tourette's syndrome, PET imaging was performed.
Twenty adults with Tourette's syndrome and 20 healthy control subjects were investigated with PET-[18F]altanserin using a bolus-infusion protocol. Regions of interest were delineated automatically on co-registered MRI images, and partial volume-corrected binding parameters were extracted from the PET images.
Comparison between control subjects and Tourette's syndrome patients showed increased specific [18F]altanserin binding, not only in the a-priori selected brain regions hypothesized to be involved in Tourette's syndrome, but also post-hoc analysis showed a global up-regulation when testing for a overall difference with a randomization test (p
Language: | English |
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Year: | 2007 |
Pages: | 245-252 |
ISSN: | 14695111 and 14611457 |
Types: | Journal article |
DOI: | 10.1017/S1461145706006559 |
ORCIDs: | Nielsen, Finn Årup |