Journal article
Infectious risk factors for individual postweaning multisystemic wasting syndrome (PMWS) development in pigs from affected farms in Spain and Denmark
Autonomous University of Barcelona1
Virology, Division of Veterinary Diagnostics and Research, National Veterinary Institute, Technical University of Denmark2
Department of Informatics and Mathematical Modeling, Technical University of Denmark3
DTU Data Analysis, Department of Informatics and Mathematical Modeling, Technical University of Denmark4
Danish Pig Production5
National Veterinary Institute, Technical University of Denmark6
Division of Veterinary Diagnostics and Research, National Veterinary Institute, Technical University of Denmark7
Section for Veterinary Epidemiology and public sector consultancy, Division of Veterinary Diagnostics and Research, National Veterinary Institute, Technical University of Denmark8
Section for Veterinary Diagnostics, Division of Veterinary Diagnostics and Research, National Veterinary Institute, Technical University of Denmark9
Division of Microbiology and Risk Assessment, National Food Institute, Technical University of Denmark10
...and 0 moreTwo prospective longitudinal studies in 13 postweaning multisystemic wasting syndrome (PMWS)-affected farms from Spain (n = 3) and Denmark (n = 10) were performed. Blood samples from pigs were longitudinally collected from 1st week until the occurrence of the PMWS outbreak. Wasted and healthy age-matched pigs were euthanized, necropsied and histopathologically characterised.
PMWS diagnosis was confirmed by means of lymphoid lesions and detection of porcine circovirus type 2 (PCV2) in these tissues by in situ hybridization or immunohistochemistry. Serological analyses were performed in longitudinally collected serum samples to detect antibodies against, PCV2, porcine reproductive and respiratory syndrome virus (PRRSV), porcine parvovirus (PPV), swine influenza virus (SIV) and Lawsonia intracellularis (law), Mycoplasma hyopneumoniae, Aujeszky’s disease virus (ADV) and Salmonella spp.
A Cox proportional hazards model was used to investigate the simultaneous effects of seroconversion and maternal immunity against the studied pathogens. Results showed that high levels of maternal immunity against PCV2 had a protecting effect in farms from both countries. Moreover, for the Danish dataset, seroconversion against law had an overall protecting effect, but for animals with very low levels of maternal antibody levels against this pathogen, the effect appeared neutral or aggravating.
Otherwise, for the Spanish dataset, maternal immunity against PPV and PRRSV gave protective and aggravating effects, respectively. In conclusion, the present study reflects the complex interaction among different pathogens and their effects in order to trigger PMWS in PCV2 infected pigs.
Language: | English |
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Year: | 2012 |
Pages: | 1231-1240 |
ISSN: | 15322661 and 00345288 |
Types: | Journal article |
DOI: | 10.1016/j.rvsc.2012.07.001 |
ORCIDs: | Stockmarr, Anders , Hjulsager, Charlotte Kristiane , Vigre, Håkan and Larsen, Lars Erik |