Journal article
Dietary determinants for Hb-acrylamide and Hb-glycidamide adducts in Danish non-smoking women
Danish Cancer Society1
University of Copenhagen2
Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark3
National Food Institute, Technical University of Denmark4
Division of Food Chemistry, National Food Institute, Technical University of Denmark5
Aarhus University6
Acrylamide (AA) is a probable human carcinogen that is formed in heat-treated carbohydrate-rich foods. The validity of FFQ to assess AA exposure has been questioned. The aim of the present cross-sectional study was to investigate dietary determinants of Hb-AA and Hb-glycidamide (GA) adducts. The study included 537 non-smoking women aged 50–65 years who participated in the Diet, Cancer and Health cohort (1993–97).
At study baseline, blood samples and information on dietary and lifestyle variables obtained from self-administered questionnaires were collected. From blood samples, Hb-AA and Hb-GA in erythrocytes were analysed by liquid chromatography/MS/MS. Dietary determinants were evaluated by multiple linear regression analyses adjusted for age and smoking behaviour among ex-smokers.
The median for Hb-AA was 35 pmol/g globin (5th percentile 17, 95th percentile 89) and for Hb-GA 21 pmol/g globin (5th percentile 8, 95th percentile 49). Of the dietary factors studied, intakes of coffee and chips were statistically significantly associated with a 4 % per 200 g/d (95 % CI 2, 7; P <0·0001) and an 18 % per 5 g/d (95 % CI 6, 31; P = 0·002) higher Hb-AA, respectively.
This model explained 17 % of the variation in Hb-AA. Intakes of coffee and biscuits/crackers were statistically significantly associated with a 3 % per 200 g/d (95 % CI 1, 6; P = 0·005) and 12 % per 10 g/d (95 % CI 3, 23; P = 0·01) higher Hb-GA, respectively. This model explained 12 % of the variation in Hb-GA.
In conclusion, only a few dietary determinants of Hb-AA and Hb-GA were identified. Thus, the present study implies that dietary intake measured by an FFQ explains only to a limited extent the variation in Hb-AA and Hb-GA concentrations.
Language: | English |
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Publisher: | Cambridge University Press |
Year: | 2011 |
Pages: | 1381-1387 |
ISSN: | 14752662 and 00071145 |
Types: | Journal article |
DOI: | 10.1017/S0007114510005003 |
ORCIDs: | Olesen, Pelle Thonning , Frandsen, Henrik Lauritz , 0000-0001-6429-7921 and 0000-0003-0609-6317 |