Journal article
Human gut microbes impact host serum metabolome and insulin sensitivity
Department of Systems Biology, Technical University of Denmark1
Steno Diabetes Centre2
Vrije Universiteit Brussel3
Technical Information Center of Denmark, Technical University of Denmark4
University of Turku5
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark6
Integrative Systems Biology, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark7
Örebro University8
University of Copenhagen9
European Molecular Biology Laboratory10
Université Paris-Saclay11
KU Leuven12
VTT Technical Research Centre of Finland Ltd.13
...and 3 moreInsulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes. Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals. The serum metabolome of insulin-resistant individuals is characterized by increased levels of branched-chain amino acids (BCAAs), which correlate with a gut microbiome that has an enriched biosynthetic potential for BCAAs and is deprived of genes encoding bacterial inward transporters for these amino acids.
Prevotella copri and Bacteroides vulgatus are identified as the main species driving the association between biosynthesis of BCAAs and insulin resistance, and in mice we demonstrate that P. copri can induce insulin resistance, aggravate glucose intolerance and augment circulating levels of BCAAs. Our findings suggest that microbial targets may have the potential to diminish insulin resistance and reduce the incidence of common metabolic and cardiovascular disorders.
Language: | English |
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Publisher: | Nature Publishing Group |
Year: | 2016 |
Pages: | 376-381 |
Journal subtitle: | International Weekly Journal of Science |
ISSN: | 14764687 and 00280836 |
Types: | Journal article |
DOI: | 10.1038/nature18646 |
ORCIDs: | Nielsen, Henrik Bjørn , Pedersen, Susanne Brix , 0000-0002-2066-7895 , 0000-0001-6991-0828 , 0000-0002-0886-9101 , 0000-0002-6024-0917 , 0000-0001-8748-3831 , 0000-0003-0316-5866 and 0000-0002-3321-3972 |