Journal article
Intraoperative Detection and Eradication of Residual Microtumors with Gap-Enhanced Raman Tags
The inability to intraoperatively diagnose and eliminate microscopic residual tumors represents a significant challenge in cancer surgery. These residual microtumors cause lethal recurrence and metastasis. Herein, we show a crucial example of Raman imaging with gap-enhanced Raman tags (GERTs) to serve as a robust platform for intraoperative detection and eradication of residual microscopic foci, which exist in surgical margins, tumor invasion, and multifocal tumor spread.
The GERTs feature gap-enhanced gold core-shell nanostructures, with Raman reporters embedding inside the interior gap junction. This nanostructure elicits highly sensitive and photostable Raman signals for microtumor detection by applying a 785 nm, low-energy laser and produces hyperthermia effects for microtumor ablation upon switching a 808 nm, high-power laser.
In the orthotopic prostate metastasis tumor model, systematic delivery of GERTs enabled precise imaging and real-time ablation of macroscopic malignant lesions around the surgical bed without damaging normal tissues. Consequently, the GERTs-based surgery prevented local recurrence and delivered 100% tumor-free survival.
These results suggest the efficiency of theranostic GERTs for precise detection and removal of residual miroctumors, broadening the avenues to apply Raman-based imaging for theranostic precision medicine.
Language: | English |
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Publisher: | American Chemical Society |
Year: | 2018 |
Pages: | 7974-7985 |
ISSN: | 1936086x and 19360851 |
Types: | Journal article |
DOI: | 10.1021/acsnano.8b02681 |
ORCIDs: | 0000-0002-6750-2617 , Han, Anpan , 0000-0002-8101-8362 and 0000-0002-3457-5772 |
Cancer theranostics Gap-enhanced Raman tag Nanomedicine Residual microtumors SDG 3 - Good Health and Well-being Surface-enhanced Raman spectroscopy
Animals Cell Line, Tumor Gold Humans Male Mice Mice, SCID Neoplasms, Experimental Prostatic Neoplasms Spectrum Analysis, Raman Tissue Distribution cancer theranostics cancertheranostics gap-enhanced Raman tag gap-enhancedRaman tag nanomedicine residual microtumors surface-enhanced Raman spectroscopy surface-enhancedRaman spectroscopy