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Journal article

The Role of Paracrine and Autocrine Signaling in the Early Phase of Adipogenic Differentiation of Adipose-derived Stem Cells

By Hemmingsen, Mette1,2; Vedel, Søren1; Skafte-Pedersen, Peder1; Sabourin, David1; Collas, Philippe3; Bruus, Henrik4,5; Dufva, Martin1,2

Edited by Engler, Adam J.

From

Department of Micro- and Nanotechnology, Technical University of Denmark1

Fluidic Array Systems and Technology, Department of Micro- and Nanotechnology, Technical University of Denmark2

University of Oslo3

Department of Physics, Technical University of Denmark4

Biophysics and Fluids, Department of Physics, Technical University of Denmark5

Using different cell densities and microfluidic perfusion cell cultures to suppress the effects of cell-released factors, we have demonstrated the significant role played by auto- or paracrine signaling in adipocyte differentiation. The cell-released factor(s) were shown to act in the recruitment phase of the differentiation process.

Language: English
Publisher: Public Library of Science
Year: 2013
Pages: e63638
ISSN: 19326203 and 1553734x
Types: Journal article
DOI: 10.1371/journal.pone.0063638
ORCIDs: Bruus, Henrik and Dufva, Martin
Keywords

Adipogenesis Adipose Tissue Autocrine Communication Biomarkers Computer Simulation Culture Media, Conditioned Humans Lipid Metabolism Medicine Models, Biological Paracrine Communication Q R Science Stem Cells Time Factors

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