Journal article · Ahead of Print article
Evaluation of the solid state form of tadalafil in sub-micron thin films using nanomechanical infrared spectroscopy
Malek Ashtar University of Technology1
Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark2
Department of Health Technology, Technical University of Denmark3
Drug Delivery and Sensing, Department of Health Technology, Technical University of Denmark4
Nanoprobes, Drug Delivery and Sensing, Department of Health Technology, Technical University of Denmark5
Assessing physical stability of drugs is important both in the development as well as in the production phase in the pharmaceutical industry. We used nanomechanical infrared (NAM-IR) spectroscopy based on photothermal response of a nanomechanical resonator, to investigate the solid state forms of tadalafil (TAD), under various storage conditions in sub-micron thin films.
The amorphous TAD was stable, when kept at normal storage conditions of 24 °C, 45% relative humidity (RH) and shielded from light, however, it crystallized after four days when it was at stress storage conditions (40 °C, 70% RH, and direct sunlight). Additionally, we found that the signals recorded with NAM-IR were comparable with the attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and that NAM-IR proved to be a suitable and time efficient method when evaluating TAD in sub 500 nm layers.
Language: | English |
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Year: | 2019 |
Pages: | 227-232 |
ISSN: | 18733476 and 03785173 |
Types: | Journal article and Ahead of Print article |
DOI: | 10.1016/j.ijpharm.2019.05.010 |
ORCIDs: | Nielsen, Line Hagner , Zor, Kinga and Boisen, Anja |