Journal article
Immune epitope database analysis resource
The immune epitope database analysis resource (IEDB-AR: http://tools.iedb.org) is a collection of tools for prediction and analysis of molecular targets of T- and B-cell immune responses (i.e. epitopes). Since its last publication in the NAR webserver issue in 2008, a new generation of peptide:MHC binding and T-cell epitope predictive tools have been added.
As validated by different labs and in the first international competition for predicting peptide:MHC-I binding, their predictive performances have improved considerably. In addition, a new B-cell epitope prediction tool was added, and the homology mapping tool was updated to enable mapping of discontinuous epitopes onto 3D structures.
Furthermore, to serve a wider range of users, the number of ways in which IEDB-AR can be accessed has been expanded. Specifically, the predictive tools can be programmatically accessed using a web interface and can also be downloaded as software packages.
| Language: | English |
|---|---|
| Publisher: | Oxford University Press |
| Year: | 2012 |
| Pages: | W525-30 |
| ISSN: | 03051048 and 13624962 |
| Types: | Journal article |
| DOI: | 10.1093/nar/gks438 |
| ORCIDs: | Lund, Ole and Nielsen, Morten |
00530, General biology - Information, documentation, retrieval and computer applications 02506, Cytology - Animal 10064, Biochemistry studies - Proteins, peptides and amino acids 15002, Blood - Blood and lymph studies 15004, Blood - Blood cell studies 34502, Immunology - General and methods B-cell immune system, blood and lymphatics Chemical Coordination and Homeostasis Computational Biology Computer Applications Immune System MHC-I MHC-II T-cell immune system, blood and lymphatics computer software package computer software epitope prediction tool mathematical and computer techniques homology mapping tool mathematical and computer techniques immune epitope database analysis resource immune response peptide
