Journal article
Surface-enhanced Raman spectroscopic study of DNA and 6-mercapto-1-hexanol interactions using large area mapping
Department of Micro- and Nanotechnology, Technical University of Denmark1
Department of Applied Mathematics and Computer Science, Technical University of Denmark2
Cognitive Systems, Department of Applied Mathematics and Computer Science, Technical University of Denmark3
Nanoprobes, Department of Micro- and Nanotechnology, Technical University of Denmark4
Copenhagen Center for Health Technology, Centers, Technical University of Denmark5
Surface Engineering, Department of Micro- and Nanotechnology, Technical University of Denmark6
Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark7
The emergence of 2D SERS substrates with large areas of hot spots has enabled data to be gathered at large scale. This work presents a statistical tool for analysing large amounts of SERS data by utilizing a peak-fitting model in a specific spectral range. By analysing the distributions of Raman intensities and peak positions it is possible to directly inspect the interplay between DNA and 6-mercapto-1-hexanol on gold covered nanopillars.
It is demonstrated that optimised functionalization parameters can be extracted from the Raman spectra directly. Using the peak-fitting approach it is possible to avoid miss-interpretation of intensity histograms, where contamination might contribute with an enhanced background and not a peak.
Language: | English |
---|---|
Year: | 2016 |
Pages: | 331-336 |
ISSN: | 18733697 and 09242031 |
Types: | Journal article |
DOI: | 10.1016/j.vibspec.2016.08.005 |
ORCIDs: | Schmidt, Mikkel Nørgaard , Jakobsen, Mogens Havsteen , Alstrøm, Tommy Sonne , Bache, Michael , Larsen, Jan and Boisen, Anja |
6-mercapto-1-hexanol Area mapping DNA Gold Peak-fitting SERS Thiol