Journal article
Flow-orthogonal bead oscillation in a microfluidic chip with a magnetic anisotropic flux-guide array
Eindhoven University of Technology1
Magnetic Systems Group, LabChip Section, Department of Micro- and Nanotechnology, Technical University of Denmark2
LabChip Section, Department of Micro- and Nanotechnology, Technical University of Denmark3
Department of Micro- and Nanotechnology, Technical University of Denmark4
A new concept for the manipulation of superparamagnetic beads inside a microfluidic chip is presented in this paper. The concept allows for bead actuation orthogonal to the flow direction inside a microchannel. Basic manipulation functionalities were studied by means of finite element simulations and results were oval-shaped steady state oscillations with bead velocities up to 500 μm/s.
The width of the trajectory could be controlled by prescribing external field rotation. Successful verification experiments were performed on a prototype chip fabricated with excimer laser ablation in polycarbonate and electroforming of nickel flux-guides. Bead velocities up to 450 μm/s were measured in a 75 μm wide channel.
By prescribing the currents in the external quadrupole magnet, the shape of the bead trajectory could be controlled.
Language: | English |
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Publisher: | Springer US |
Year: | 2011 |
Pages: | 353-359 |
Journal subtitle: | Biomems and Biomedical Nanotechnology |
ISSN: | 15728781 and 13872176 |
Types: | Journal article |
DOI: | 10.1007/s10544-010-9503-5 |
ORCIDs: | Hansen, Mikkel Fougt |
Anisotropy Biomedical Engineering Biophysics and Biological Physics Engineering Engineering Fluid Dynamics Magnetic flux-guides Magnetics Microfluidic Analytical Techniques Microfluidics Microspheres Motion Nanotechnology Polycarboxylate Cement Quadrupole magnet Shape-anisotropy Superparamagnetic beads polycarbonate