Journal article
Tritium labelling of PACAP-38 using a synthetic diiodinated precursor peptide
Biomedical Tracers, Radiation Research Division, Risø National Laboratory for Sustainable Energy, Technical University of Denmark1
Radiation Research Division, Risø National Laboratory for Sustainable Energy, Technical University of Denmark2
Risø National Laboratory for Sustainable Energy, Technical University of Denmark3
Copenhagen University Hospital Herlev and Gentofte4
In the interest of developing efficient methods for tritium labelling peptides, we here demonstrate the successful labelling of PACAP-38 (pituitary adenylate cyclase-activating polypeptide), a 38-mer peptide, using a synthetic diiodinated PACAP-38 precursor. In this example, we employ standard hydrogenation chemistry with the use of a heterogeneous palladium catalyst and carrier-free tritium gas on a tritium manifold system.
Language: | English |
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Year: | 2012 |
Pages: | 1-4 |
ISSN: | 10991344 and 03624803 |
Types: | Journal article |
DOI: | 10.1002/jlcr.1941 |