Journal article
Loading of Drug-Polymer Matrices in Microreservoirs for Oral Drug Delivery
Department of Micro- and Nanotechnology, Technical University of Denmark1
Biomaterial Microsystems, Department of Micro- and Nanotechnology, Technical University of Denmark2
Nanoprobes, Department of Micro- and Nanotechnology, Technical University of Denmark3
Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark4
For major advances in microfabricated drug delivery systems (DDS), fabrication methods with high throughput using biocompatible polymers are required. Once these DDS are fabricated, loading of drug poses a significant challenge. Here, hot punching is presented as an innovative method for drug loading in microfabricated DDS.
The microfabricated DDS are microcontainers fabricated in photoresist SU-8 and biopolymer poly-L-lactic-acid (PLLA). Furosemide (F) drug is embedded in poly-ε-caprolactone (PCL) polymer matrix. This F-PCL drug polymer matrix is loaded in SU-8 and PLLA microcontainers using hot punching with >99% yield.
Thus, it is illustrated that hot punching allows high-throughput, parallel loading of 3D polymer microcontainers with drug-polymer matrices in a single process step.
| Language: | English |
|---|---|
| Year: | 2017 |
| Pages: | 1600366 |
| ISSN: | 14392054 and 14387492 |
| Types: | Journal article |
| DOI: | 10.1002/mame.201600366 |
| ORCIDs: | Petersen, Ritika Singh , Keller, Stephan Sylvest and Boisen, Anja |
