Journal article
Omics and multi-omics approaches to study the biosynthesis of secondary metabolites in microorganisms
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark1
Research Groups, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark2
New Bioactive Compounds, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark3
Center for Microbial Secondary Metabolites, Centers, Technical University of Denmark4
Natural products produced by microorganisms represent the main source of bioactive molecules. The development of high-throughput (omics) techniques have importantly contributed to the renaissance of new antibiotic discovery increasing our understanding of complex mechanisms controlling the expression of biosynthetic gene clusters (BGCs) encoding secondary metabolites.
In this context this review highlights recent progress in the use and integration of ‘omics’ approaches with focuses on genomics, transcriptomics, proteomics metabolomics meta-omics and combined omics as powerful strategy to discover new antibiotics.
Language: | English |
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Year: | 2018 |
Pages: | 109-116 |
ISSN: | 18790364 and 13695274 |
Types: | Journal article |
DOI: | 10.1016/j.mib.2018.03.004 |
ORCIDs: | Weber, Tilmann and Palazzotto, Emilia |