Journal article
High-fat feeding induces mobilization of vitamin C in obese prone rats
In obesity and dyslipidemia, hydrolysis of triacylglycerol (TAG) into non-esterified fatty acids (NEFAs) may contribute to insulin resistance, and production of oxygenated, bioactive polyunsaturated fatty acids may increase oxidative stress. Here we show that after six weeks of high-fat feeding of obese prone rats (Crl:OP(CD), vitamin C was increased both in liver (P < 0.01) and plasma (P < 0.001), while both TAG (P < 0.01) and NEFA (P < 0.001) were lower than in low-fat fed control rats.
Hepatic vitamin C biosynthesis was similar between groups, indicating that a new steady state level was established with a higher vitamin C level adequate for supplying the systemic needs. Glucose and insulin sensitivity were unaffected at this stage. Eventually, the mobilization of vitamin C may be seen as a mechanism to protect the host against insulin resistance.
Language: | English |
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Publisher: | Elsevier BV |
Year: | 2018 |
Pages: | 167-169 |
ISSN: | 15322661 and 00345288 |
Types: | Journal article |
DOI: | 10.1016/j.rvsc.2018.06.011 |
ORCIDs: | 0000-0002-6514-8407 and 0000-0003-1575-2507 |