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Journal article

Study of Paclitaxel-Treated HeLa Cells by Differential Electrical Impedance Flow Cytometry

By Kirkegaard, Julie1,2; Clausen, Casper Hyttel1,3; Rodriguez-Trujíllo, Romén1; Svendsen, Winnie Edith1,3

From

Department of Micro- and Nanotechnology, Technical University of Denmark1

Polymer Microsystems for Medical Diagnostics, Department of Micro- and Nanotechnology, Technical University of Denmark2

Nano Bio Integrated Systems, Department of Micro- and Nanotechnology, Technical University of Denmark3

This work describes the electrical investigation of paclitaxel-treated HeLa cells using a custom-made microfluidic biosensor for whole cell analysis in continuous flow. We apply the method of differential electrical impedance spectroscopy to treated HeLa cells in order to elucidate the changes in electrical properties compared with non-treated cells.

We found that our microfluidic system was able to distinguish between treated and non-treated cells. Furthermore, we utilize a model for electrical impedance spectroscopy in order to perform a theoretical study to clarify our results. This study focuses on investigating the changes in the electrical properties of the cell membrane caused by the effect of paclitaxel.

We observe good agreement between the model and the obtained results. This establishes the proof-of-concept for the application in cell drug therapy.

Language: English
Publisher: MDPI
Year: 2014
Pages: 257-272
ISSN: 20796374
Types: Journal article
DOI: 10.3390/bios4030257
ORCIDs: Svendsen, Winnie Edith
Keywords

Cell properties Electrical impedance spectroscopy HeLa cells Paclitaxel

Other keywords

Biotechnology TP248.13-248.65 cell properties electrical impedance spectroscopy paclitaxel

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