Journal article
Pervasive Sharing of Genetic Effects in Autoimmune Disease
Massachusetts General Hospital1
Feinstein Institute for Medical Research2
Karolinska Institutet3
Mount Sinai Hospital4
Queen Mary University of London5
University of Groningen6
University of Manchester7
University of Virginia8
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark9
Department of Systems Biology, Technical University of Denmark10
University of Cambridge11
University of Michigan, Ann Arbor12
Wellcome Sanger Institute13
Genentech, Inc.14
Yale University15
Massachusetts General Hospital/Harvard Medical School16
...and 6 moreGenome-wide association (GWA) studies have identified numerous, replicable, genetic associations between common single nucleotide polymorphisms (SNPs) and risk of common autoimmune and inflammatory (immune-mediated) diseases, some of which are shared between two diseases. Along with epidemiological and clinical evidence, this suggests that some genetic risk factors may be shared across diseases-as is the case with alleles in the Major Histocompatibility Locus.
In this work we evaluate the extent of this sharing for 107 immune disease-risk SNPs in seven diseases: celiac disease, Crohn's disease, multiple sclerosis, psoriasis, rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes. We have developed a novel statistic for Cross Phenotype Meta-Analysis (CPMA) which detects association of a SNP to multiple, but not necessarily all, phenotypes.
With it, we find evidence that 47/107 (44%) immune-mediated disease risk SNPs are associated to multiple-but not all-immune-mediated diseases (SNP-wise P-CPMA
Language: | English |
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Publisher: | Public Library of Science |
Year: | 2011 |
Pages: | e1002254 |
ISSN: | 15537404 and 15537390 |
Types: | Journal article |
DOI: | 10.1371/journal.pgen.1002254 |