Journal article
Efficient Hyperpolarization of U-13 C-Glucose Using Narrow-Line UV-Generated Labile Free Radicals
Center for Hyperpolarization in Magnetic Resonance, Centers, Technical University of Denmark1
Center for Magnetic Resonance, Department of Electrical Engineering, Technical University of Denmark2
Department of Electrical Engineering, Technical University of Denmark3
Aix-Marseille Université4
University of Cambridge5
Free radicals generated by UV-light irradiation of a frozen solution containing a fraction of pyruvic acid (PA) have demonstrated their dissolution dynamic nuclear polarization (dDNP) potential, providing up to 30 % [1-13C]PA liquid-state polarization. Moreover, their labile nature has proven to pave a way to nuclear polarization storage and transport.
Herein, differently from the case of PA, the issue of providing dDNP UV-radical precursors (trimethylpyruvic acid and its methyl-deuterated form) not involved in any metabolic pathway was investigated. The 13C dDNP performance was evaluated for hyperpolarization of [U-13 C6 ,1,2,3,4,5,6,6-d7 ]-d-glucose.
The generated UV-radicals proved to be versatile and highly efficient polarizing agents, providing, after dissolution and transfer (10 s), a 13 C liquid-state polarization of up to 32 %.
| Language: | English |
|---|---|
| Year: | 2018 |
| Pages: | 1334-1339 |
| ISSN: | 15213773 and 14337851 |
| Types: | Journal article |
| DOI: | 10.1002/anie.201810522 |
| ORCIDs: | Capozzi, Andrea , 0000-0001-7306-3326 , 0000-0001-5076-8526 , 0000-0002-8484-3448 , Karlsson, Magnus , Lerche, Mathilde Hauge , 0000-0003-4320-4313 and Ardenkjær-Larsen, Jan Henrik |
