Journal article · Conference paper
An artificial pancreas based on simple control algorithms and physiological insight
We present a simple control algorithm for a single-hormone artificial pancreas (AP). The AP consists of a continuous glucose monitor (CGM) measuring the interstitial glucose concentration, a control algorithm computing the insulin to administer, and an insulin pump dosing the insulin. The control algorithm is based on insights into the underlying dynamics of the glucose-insulin dynamics in people with type 1 diabetes.
The main components in this control system are 1) an insulin bolus calculator to compensate for carbohydrates in meals, 2) a run-to-run algorithm for adjusting the basal insulin to long-term metabolic variations, and 3) a micro-bolus correction of the basal insulin to compensate for short-term variations in the endogenous insulin production and insulin sensitivity.
Language: | English |
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Year: | 2019 |
Pages: | 1018-1023 |
Proceedings: | 12th IFAC Symposium on Dynamics and Control of Process Systems |
ISSN: | 24058963 and 24058971 |
Types: | Journal article and Conference paper |
DOI: | 10.1016/j.ifacol.2019.06.196 |
ORCIDs: | Jørgensen, John Bagterp , Boiroux, Dimitri and Mahmoudi, Zeinab |