Journal article
Petasis Three-Component Coupling Reactions of Hydrazides for the Synthesis of Oxadiazolones and Oxazolidinones
Department of Chemistry, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark, and Department of International Health, Immunology and Microbiology, University of Copenhagen, DK-2200 Copenhagen, Denmark
An application of readily available hydrazides in the Petasis 3-component coupling reaction is presented. An investigation of the substrate scope was performed to establish a general, synthetically useful protocol for the formation of hydrazido alcohols, which were selectively converted to oxazolidinone and oxadiazolone ring systems through triphosgene-mediated cyclization reactions.
Language: | English |
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Publisher: | American Chemical Society |
Year: | 2012 |
Pages: | 640-643 |
ISSN: | 15237052 and 15237060 |
Types: | Journal article |
DOI: | 10.1021/ol203280b |