Journal article
Twelve single nucleotide polymorphisms on chromosome 19q13.2-13.3: linkage disequilibria and associations with basal cell carcinoma in Danish psoriatic patients
The genetic susceptibility to basal cell carcinoma (BCC) among Danish psoriatic patients was investigated in association studies with 12 single nucleotide polymorphisms on chromosome 19q13.2-3. The results show a significant association between BCC and the A-allele of a polymorphism in ERCCI exon4 (Odds ratio 12;95% Confidence Interval 1.17-124; p(chi2, two-side) = 0.019) and to a lesser extent with XPD exon6 (p = 0.06).
This is in accordance with recent studies of a different group of BCC cases (Rockenbauer et al. (in press) Carcinogenesis; Yin et al. (manuscript submitted for publication). Cancer Epidemiol. Biomarkers Prev), which places two highly influential markers between these two genes. The analysis also confirmed that considerable linkage disequilibrium exists between SNPs both within genes and between genes in this region.
The combined studies suggest that genetic variation in nucleotide excision repair is of importance for the development of BCC.
| Language: | English |
|---|---|
| Publisher: | Kluwer Academic Publishers-Plenum Publishers |
| Year: | 2003 |
| Pages: | 27-37 |
| ISSN: | 15734927 and 00062928 |
| Types: | Journal article |
| DOI: | 10.1023/a:1020970428370 |
Adult Biochemistry, general Biomedicine Carcinoma, Basal Cell Chromosomes, Human, Pair 19 DNA Helicases DNA Mutational Analysis DNA Repair DNA repair DNA-Binding Proteins Denmark ERCC1 protein, human ERCC2 protein, human Endonucleases Genetic Predisposition to Disease Human Genetics Humans Linkage Disequilibrium Medical Microbiology Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Proteins Psoriasis Skin Neoplasms Transcription Factors Xeroderma Pigmentosum Group D Protein Zoology basal cell carcinoma epidemiology linkage disequilibria nucleotide polymorphism psoriasis
