Journal article
Grey-box pharmacokinetic/pharmacodynamic modelling of a euglycaemic clamp study
Grey-box pharmacokinetic/pharmacodynamic (PK/PD) modelling is presented as a promising way of modelling the pharmacokinetics and pharmacodynamics of the in vivo system of insulin and glucose and to estimate model and derived PK/PD parameters. The concept behind grey-box modelling consists in using a priori physiological knowledge along with information from data in the estimation of model parameters.
The PK/PD properties of two types of insulin are investigated in a euglycaemic clamp study where a single bolus of insulin is injected subcutaneously. The effect of insulin on the glucose disappearance is investigated by artificially maintaining a blood glucose concentration close to the normal fasting level.
The infused glucose needed to maintain the clamped blood glucose concentration can therefore be used as a measure for the glucose utilization. The PK and PD parameters are successfully estimated simultaneously thereby describing the uptake, distribution, and effect of the two different types of insulin.
Language: | English |
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Publisher: | Springer-Verlag |
Year: | 2004 |
Pages: | 591-604 |
ISSN: | 14321416 and 03036812 |
Types: | Journal article |
DOI: | 10.1007/s00285-003-0257-z |
ORCIDs: | Madsen, Henrik |
Adolescent Adult Area Under Curve Blood Glucose C-Reactive Protein Compartmental modelling Cross-Over Studies Double-Blind Method Euglycaemic clamp Glucose Clamp Technique Grey-box modelling Humans Insulin Insulin Aspart Insulin, Regular, Pork Kalman filtering ML estimation Male Mathematics Models, Biological Stochastic differential equations insulin, neutral