Journal article
Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study
OBJECTIVES: Positron emission tomography (PET) studies have shown that cortical cerebral metabolic rate of glucose (CMRglc) is reduced in multiple sclerosis (MS). Quantitative magnetic resonance spectroscopy (MRS) measures of N-acetyl-aspartate (NAA) normalized to creatine (NAA/Cr) assess neuronal deterioration, and several studies have shown reductions in MS.
Furthermore, both PET and MRS reductions correlate with cognitive dysfunction in MS. Our aim was to determine if changes in cortical CMRglc in early MS correlate with NAA/Cr measurements of neuronal deterioration, as well as cognitive dysfunction and neurological disability. METHODS: We studied 20 recently diagnosed, clinically definite, relapsing-remitting MS patients.
Global and cortical CMRglc was estimated using PET with 18-F-deoxyglucose and NAA/Cr ratio was measured using multislice echo-planar spectroscopic imaging. All subjects were neuro-psychologically tested and a cognitive dysfunction factor (CDF) was calculated. RESULTS: Cortical CMRglc correlated with cortical NAA/Cr (r = 0·45; P
| Language: | English |
|---|---|
| Publisher: | Taylor & Francis |
| Year: | 2012 |
| Pages: | 52-58 |
| Journal subtitle: | A Journal of Progress in Neurosurgery, Neurology and Neuro Sciences |
| ISSN: | 17431328 and 01616412 |
| Types: | Journal article |
| DOI: | 10.1179/1743132811Y.0000000059 |
| ORCIDs: | 0000-0001-7712-8596 and Hanson, Lars G. |
Adult Aspartic Acid Brain Cerebral Cortex Cerebral metabolism Cognition Disorders Cognitive dysfunction Creatine Female Glucose Humans MRI MRS Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Middle Aged Multiple Sclerosis, Relapsing-Remitting Multiple sclerosis PET Positron-Emission Tomography Regression Analysis Young Adult
