Journal article
New interpretation of arterial stiffening due to cigarette smoking using a structurally motivated constitutive model
Biomedical Engineering, Department of Electrical Engineering, Technical University of Denmark1
Department of Electrical Engineering, Technical University of Denmark2
Center for Fast Ultrasound Imaging, Centers, Technical University of Denmark3
Copenhagen University Hospital Herlev and Gentofte4
Yale University5
Cigarette smoking is the leading self-inflicted risk factor for cardiovascular diseases; it causes arterial stiffening with serious sequelea including atherosclerosis and abdominal aortic aneurysms. This work presents a new interpretation of arterial stiffening caused by smoking based on data published for rat pulmonary arteries.
A structurally motivated ‘‘four fiber family’’ constitutive relation was used to fit the available biaxial data and associated best-fit values of material parameters were estimated using multivariate nonlinear regression. Results suggested that arterial stiffening caused by smoking was reflected by consistent increase in an elastin-associated parameter and moreover by marked increase in the collagen-associated parameters.
That is, we suggest that arterial stiffening due to cigarette smoking appears to be isotropic, which may allow simpler phenomenological models to capture these effects using a single stiffening parameter similar to the approach in isotropic continuum damage mechanics. There is a pressing need, however, for more detailed histological information coupled with more complete biaxial mechanical data for a broader range of systemic arteries.
Language: | English |
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Year: | 2011 |
Pages: | 1209-1211 |
ISSN: | 18732380 and 00219290 |
Types: | Journal article |
DOI: | 10.1016/j.jbiomech.2011.01.032 |
ORCIDs: | Enevoldsen, Marie Sand , Henneberg, Kaj-Åge and Jensen, Jørgen Arendt |