Journal article
Modular, Lightweight, Wireless Potentiostat-on-a-Disc for Electrochemical Detection in Centrifugal Microfluidics
Department of Health Technology, Technical University of Denmark1
Drug Delivery and Sensing, Department of Health Technology, Technical University of Denmark2
Nanoprobes, Drug Delivery and Sensing, Department of Health Technology, Technical University of Denmark3
Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark4
University of Naples Federico II5
Eindhoven University of Technology6
National Taiwan University7
Polytechnic University of Milan8
Interfacing electrochemical sensors in a lab-on-a-disc (LoD) system with a potentiostat is often tedious and challenging. We here present the first multichannel, modular, lightweight, and wirelessly powered, custom-built potentiostat-on-a-disc (PoD) for centrifugal microfluidic applications. The developed potentiostat is in the form factor of a typical digital video disc (DVD) and weighs only 127 g.
The design of the potentiostat facilitates easy and robust interfacing with the electrodes in the LoD system, while enabling real-time electrochemical detection during rotation. The device can perform different electroanalytical techniques such as cyclic voltammetry, square wave voltammetry, and amperometry while being controlled by custom-made software.
Measurements were conducted with and without rotation using both in-house fabricated and commercial electrodes. The performance of the PoD was in good agreement with the results obtained using a commercial potentiostat with a measured current resolution of 200 pA. As a proof of concept, we performed a real-time release study of an electrochemically active compound from microdevices used for drug delivery.
Language: | English |
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Publisher: | American Chemical Society |
Year: | 2019 |
Pages: | 11620-11628 |
ISSN: | 15206882 , 15204782 and 00032700 |
Types: | Journal article |
DOI: | 10.1021/acs.analchem.9b02026 |
ORCIDs: | Thoppe Rajendran, Sriram , Nielsen, Line Hagner , Hwu, En Te , Zor, Kinga , Boisen, Anja and 0000-0003-0094-4063 |