Journal article
Targeting Chromosomal Instability and Tumour Heterogeneity in HER2-Positive Breast Cancer
Chromosomal instability (CIN) is a common cause of tumour heterogeneity and poor prognosis in solid tumours and describes cell-cell variation in chromosome structure or number across a tumour population. In this article we consider evidence suggesting that CIN may be targeted and may influence response to distinct chemotherapy regimens, using HER2-positive breast cancer as an example.
Pre-clinical models have indicated a role for HER2 signalling in initiating CIN and defective cell-cycle control, and evidence suggests that HER2-targeting may attenuate this process. Anthracyclines and platinum agents may target tumours with distinct patterns of karyotypic complexity, whereas taxanes may have preferential activity in tumours with relative chromosomal stability.
A greater understanding of karyotypic complexity and identification of methods to directly examine and target CIN may support novel strategies to improve outcome in cancer. J. Cell. Biochem. 111: 782-790, 2010.
Language: | English |
---|---|
Publisher: | Wiley Subscription Services, Inc., A Wiley Company |
Year: | 2010 |
Pages: | 782-790 |
ISSN: | 10974644 , 07331959 and 07302312 |
Types: | Journal article |
DOI: | 10.1002/jcb.22781 |