Journal article
Synthesis of tetrahydro-β-carbolines via isomerization of N-allyltryptamines: a metal-catalyzed variation on the Pictet–Spengler theme
An efficient and broadly applicable alternative to the classical Pictet–Spengler synthesis of tetrahydro-β-carbolines is presented. The method relies on metal-catalyzed isomerization of allylic amines to form reactive iminium intermediates which can be trapped by a tethered indole nucleophile.
Language: | English |
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Publisher: | The Royal Society of Chemistry |
Year: | 2012 |
Pages: | 3345-3347 |
ISSN: | 1364548x and 13597345 |
Types: | Journal article |
DOI: | 10.1039/c2cc17704h |