Journal article
The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk
German Cancer Research Center1
Hellenic Health Foundation2
German Institute of Human Nutrition Potsdam-Rehbruecke3
Cancer Research and Prevention Institute4
Istituto Nazionale dei Tumori5
CPO Piemonte6
University of Naples Federico II7
'Civic MP Arezzo' Hospital8
University Medical Centre Utrecht9
National Institute of Public Health and the Environment10
University of Tromsø – The Arctic University of Norway11
International Agency for Research on Cancer12
Murcia Regional Health Council13
Catalan Institute of Oncology14
Consejería de Salud y Servicios Sanitarios Principado de Asturias15
Public University of Navarre16
Public Health Division of Gipuzkoa17
Andalusian School of Public Health18
Umeå University19
University of Oxford20
University of Cambridge21
Imperial College London22
Universite Claude Bernard Lyon 123
FoodDTU, Centers, Technical University of Denmark24
Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark25
National Food Institute, Technical University of Denmark26
Danish Cancer Society27
Aalborg University Hospital28
Institut Gustave Roussy29
National and Kapodistrian University of Athens30
...and 20 moreBackground The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype.
Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC).
Methods we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk. Results and Conclusions In this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.
| Language: | English |
|---|---|
| Publisher: | BioMed Central |
| Year: | 2010 |
| Pages: | 563 |
| ISSN: | 14712407 |
| Types: | Journal article |
| DOI: | 10.1186/1471-2407-10-563 |
| ORCIDs: | 0000-0001-6429-7921 |
Adipose Tissue Adult Aged Body Mass Index Breast Cancer Breast Cancer Risk Breast Neoplasms Case-Control Studies Cohort Studies Female Genome-Wide Association Study Genotype Humans INSIG2 protein, human Intracellular Signaling Peptides and Proteins Membrane Proteins Menopausal Status Middle Aged Models, Genetic Neoplasm Invasiveness Neoplasms. Tumors. Oncology. Including cancer and carcinogens Polymorphism, Genetic RC254-282 Risk Unconditional Logistic Regression
