Journal article
Pseudogene repair driven by selection pressure applied in experimental evolution
University of California at San Diego1
ALE Technology & Software Development, Research Groups, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark2
Network Reconstruction in Silico Biology, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark3
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark4
Big Data 2 Knowledge, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark5
Pseudogenes represent open reading frames that have been damaged by mutations, rendering the gene product non-functional. Pseudogenes are found in many genomes and are not always eliminated, even if they are potentially ‘wasteful’. This raises a fundamental question about their prevalence. Here we report pseudogene efeU repair that restores the iron uptake system of Escherichia coli under a designed selection pressure during adaptive laboratory evolution.
Language: | English |
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Publisher: | Nature Publishing Group UK |
Year: | 2019 |
Pages: | 386-389 |
ISSN: | 20585276 |
Types: | Journal article |
DOI: | 10.1038/s41564-018-0340-2 |
ORCIDs: | Feist, Adam , Palsson, Bernhard , 0000-0002-3720-4301 and 0000-0003-3240-3659 |