Journal article
Systems biology solutions for biochemical production challenges
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark1
iLoop, Translational Management, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark2
Synthetic Biology Tools for Yeast, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark3
Research Groups, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark4
Global Econometric Modeling, Research Groups, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark5
There is an urgent need to significantly accelerate the development of microbial cell factories to produce fuels and chemicals from renewable feedstocks in order to facilitate the transition to a biobased society. Methods commonly used within the field of systems biology including omics characterization, genome-scale metabolic modeling, and adaptive laboratory evolution can be readily deployed in metabolic engineering projects.
However, high performance strains usually carry tens of genetic modifications and need to operate in challenging environmental conditions. This additional complexity compared to basic science research requires pushing systems biology strategies to their limits and often spurs innovative developments that benefit fields outside metabolic engineering.
Here we survey recent advanced applications of systems biology methods in engineering microbial production strains for biofuels and -chemicals.
Language: | English |
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Year: | 2017 |
Pages: | 85-91 |
ISSN: | 18790429 and 09581669 |
Types: | Journal article |
DOI: | 10.1016/j.copbio.2016.11.018 |
ORCIDs: | Hansen, Anne Sofie Lærke , Lennen, Rebecca M , Sonnenschein, Nikolaus and Herrgard, Markus |