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Journal article

Optical microassembly platform for constructing reconfigurable microenvironment for biomedical studies

By Rodrigo, Peter John1,2; Kelemen, Lóránd; Palima, Darwin2,3; Alonzo, Carlo Amadeo4; Ormos, Pál; Glückstad, Jesper2,3

From

Optical Sensor Technology, Department of Photonics Engineering, Technical University of Denmark1

Department of Photonics Engineering, Technical University of Denmark2

Teraherts Technologies and Biophotonics, Department of Photonics Engineering, Technical University of Denmark3

Risø National Laboratory for Sustainable Energy, Technical University of Denmark4

Cellular development is highly influenced by the surrounding microenvironment. We propose user-reconfigurable microenvironments and bio-compatible scaffolds as an approach for understanding cellular development processes. We demonstrate a model platform for constructing versatile microenvironments by fabricating morphologically complex microstructures by two-photon polymerization (2PP) and then assembling these archetypal building blocks into various configurations using multiple, real-time configurable counterpropagating-beam (CB) traps.

The demonstrated capacity for handling feature-rich microcomponents may be further developed into a eneralized microassembly platform.

Language: English
Year: 2009
Pages: 6578-6583
ISSN: 10944087
Types: Journal article
DOI: 10.1364/OE.17.006578
ORCIDs: Rodrigo, Peter John
Keywords

Biomedical Engineering Cell Culture Techniques Cell Separation Computer-Aided Design Equipment Design Equipment Failure Analysis Optical Devices Optical Tweezers Reproducibility of Results Sensitivity and Specificity

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