Journal article
Biocatalytic process development using microfluidic miniaturized systems
The increasing interest in biocatalytic processes means there is a clear need for a new systematic development paradigm which encompasses both protein engineering and process engineering. This paper argues that through the use of a new microfluidic platform, data can be collected more rapidly and integrated with process modeling, can provide the basis for validating a reduced number of potential processes.
The miniaturized platform should use a smaller reagent inventory and make better use of precious biocatalysts. The EC funded BIOINTENSE project will use ω-transaminase based synthesis of chiral amines as a test-bed for assessing the viability of such a high throughput biocatalytic process development, and in this paper, such a vision for the future is presented.
Language: | English |
---|---|
Publisher: | De Gruyter |
Year: | 2014 |
Pages: | 23-31 |
ISSN: | 21919550 and 21919542 |
Types: | Journal article |
DOI: | 10.1515/gps-2013-0089 |
ORCIDs: | Krühne, Ulrich , Ringborg, Rolf Hoffmeyer , Pereira Rosinha, Ines , Gernaey, Krist V. and Woodley, John M. |
Chemistry QD1-999 Reviews biocatalysis microfluidics process development transaminase